New and exciting research is still being conducted on BCAAs and their applications to muscle growth, fat loss, and performance. There are not many supplements in existence that have the ability to affect growth and performance through as many different pathways as BCAAs. While BCAAs have proven benefits as a building block of muscle tissue, their benefits as signaling molecules are truly just being understood. In time BCAAs may just prove to be the most valuable supplement at our disposal. So the next time someone accuses you of being just another meathead talking about protein all the time, you can show them that it is more than just eating plates of chicken and beef…it’s science!
However, anecdotal reports of gastric distress(13) suggest that some individuals may have difficulty absorbing CR in the amounts provided by a CR supplement. To aid in trans-membrane movement, ethyl esterification (akin to the acetylation of salicylic acid to make aspirin, . acetylsalycylic acid) of drugs or other substances is commonly employed to bypass normal means of uptake, enhance bioavailability and reduce side effects(14). Although scientific investigation of the pharmacokinetics CR ethyl ester (CEE) is lacking, anecdotal reports of increased body mass without gastric discomfort are consistent with the abrupt weight gain noted in numerous research studies of CR monohydrate supplementation(15-22), suggesting the CEE does indeed make its way to skeletal muscle.