ANABOLICS 11th Edition is the latest update to this bestselling Anabolic Steroid Reference Guide. The latest edition is 7 years in the making, and includes deta ... iled coverage of new topics including SARMs (Selective Androgen Receptor Modulators), Peptides, Non-Steroidal Anabolic Agents... and of course, the most detailed coverage of Anabolic Steroids available in any reference, including discussions on drug pharmacology, side effects, side effect mitigation, cycling, efficacious dosing, global availability, and counterfeit detection.
The actual mechanism in which testosterone elicits these changes is somewhat complex. When free in the blood stream, the testosterone molecule is available to interact with various cells in the body. This includes skeletal muscle cells, as well as skin, scalp, kidney, bone, central nervous system, and prostate tissues. Testosterone binds with a cellular target in order to exert its activity, and will, therefore, effect only those body cells that posses the proper hormone receptor site (specifically the androgen receptor). This process can be likened to a lock and key system, with each receptor (lock) only being activated by a particular type of hormone (key). During this interaction, the testosterone molecule will become bound to the intracellular receptor site (located in the cytosol, not on the membrane surface), forming a new “receptor complex.” This complex (hormone + receptor site) will then migrate to the cell’s nucleus, where it will attach to a specific section of the cell’s DNA, referred to as the hormone response element. This will activate the transcription of specific genes, which in the case of a skeletal muscle cell will ultimately cause (among other things) an increase in the synthesis of the two primary contractile proteins, actin and myosin (muscular growth). Carbohydrate storage in muscle tissue may be increased due to androgen action as well.
These latest miraculous gains by Thibaudeau are a little contradictory because, while he’s said repeatedly on their forum that he could get much bigger if he wanted to, he’s also been saying that he doesn’t want to/can’t because of health issues (and I believe he also said that he only took steroids experiementally for a little while when he was a teenager). He clearly must have changed his mind, however, because he’s just claimed to have gained more muscle in 6 weeks than many drug-free bodybuilders of his stature gain in a lifetime of training. He’s doing very well – he’s now carrying over 40 pounds more muscle than the world’s best drug-free bodybuilding champions of his height (which is also well over twice as much muscle as they’ve managed to build).