This research study is testing alendronate, an FDA approved medication for osteoporosis. This medication is not yet approved by the FDA for asthma treatment. The purpose of this study is to find out if alendronate affects the loss of bronchoprotection in patients with asthma who are taking beta-2-agonists. Beta-2-agonists are bronchodialating asthma medications such as albuterol and salmeterol. Bronchodilators are inhaled medicines that relax the muscles in the airway. This makes the airway bigger so it is easier to breathe. They also protect against airway narrowing when you are exposed to your asthma triggers.
Approximately million persons in the United States, including 7 million children, had the diagnosis of asthma as of 2010. 1 It is reported that million children experienced at least one asthma exacerbation in 2011. 2 Between 1995 and 2010, exacerbations accounted for one-third of all hospital admissions for children younger than 15 years. 3 Asthma caused 3,345 . deaths in 2011, 4 and it accounts for $ billion annually in direct health care costs. 5 The management of asthma involves care plans, chronic medications, and monitoring and self-care for acute exacerbations. Therapeutic agents used in the chronic management of asthma aim to prevent symptoms by controlling airway inflammation and hyperreactivity. This article reviews the currently available medications and complementary agents for chronic asthma management. A previous article in American Family Physician discussed the management of acute exacerbations. 6
In March 2011, China's Ministry of Agriculture said the government would launch a one-year crackdown on illegal additives in pig feed, after a subsidiary of Shuanghui Group , China's largest meat producer, was exposed for using clenbuterol-contaminated pork in its meat products. A total of 72 people in central Henan Province, where Shuanghui is based, were taken into police custody for allegedly producing, selling or using clenbuterol.  The situation has dramatically improved in China since September 2011, when a ban of clenbuterol was announced by China’s Ministry of Agriculture.