Cardiovascular damage from steroids

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Cannabidiol (CBD) has beneficial effects in disorders as wide ranging as diabetes, Huntington's disease, cancer and colitis. Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system. CBD has direct actions on isolated arteries, causing both acute and time-dependent vasorelaxation. In vitro incubation with CBD enhances the vasorelaxant responses in animal models of impaired endothelium-dependent vasorelaxation. CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models and reduces the vascular hyperpermeability associated with such environments. A common theme throughout these studies is the anti-inflammatory and anti-oxidant effect of CBD. In the heart, in vivo CBD treatment protects against ischaemia-reperfusion damage and against cardiomyopathy associated with diabetes. Similarly, in a different model of ischaemia-reperfusion, CBD has been shown to reduce infarct size and increase blood flow in animal models of stroke, sensitive to 5HT(1A) receptor antagonism. Although acute or chronic CBD treatment seems to have little effect on haemodynamics, CBD reduces the cardiovascular response to models of stress, applied either systemically or intracranially, inhibited by a 5HT(1A) receptor antagonist. In blood, CBD influences the survival and death of white blood cells, white blood cell migration and platelet aggregation. Taken together, these preclinical data appear to support a positive role for CBD treatment in the heart, and in peripheral and cerebral vasculature. However, further work is required to strengthen this hypothesis, establish mechanisms of action and whether similar responses to CBD would be observed in humans.

When fatty materials such as cholesterol form deposits on the walls of the vessels (known as plaque), furring up the artery and reducing the space for blood to flow, this is described as arteriosclerosis or atherosclerosis. If the plaque ruptures the artery walls, blood cells (called platelets) try to repair the damage, but this will cause a clot to form. Over time, the walls of the blood vessels lose their elasticity. This can contribute to the development of high blood pressure or hypertension, which can cause more damage to the blood vessels.

A study done at the School of Biomedical Sciences in Australia examined rats that were fed a high fat and high carbohydrate diet for 16 weeks. The rats that were not treated  developed signs of elevated abdominal and hepatic fat deposition, collagen deposition in heart and liver, cardiac stiffness and oxidative stress markers. The rats that were treated with olive leaf extracts had improved or normalized cardiovascular, hepatic (liver function) and metabolic signs . This study suggests that olive leaf extracts reverse cardiovascular stress and chronic, disease-causing inflammation .

Cardiovascular damage from steroids

cardiovascular damage from steroids

A study done at the School of Biomedical Sciences in Australia examined rats that were fed a high fat and high carbohydrate diet for 16 weeks. The rats that were not treated  developed signs of elevated abdominal and hepatic fat deposition, collagen deposition in heart and liver, cardiac stiffness and oxidative stress markers. The rats that were treated with olive leaf extracts had improved or normalized cardiovascular, hepatic (liver function) and metabolic signs . This study suggests that olive leaf extracts reverse cardiovascular stress and chronic, disease-causing inflammation .

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