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A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.
These ingredients can be an asset to any PCT. One way to help control these side effects is to use some of them during the cycle, such as celery seed, milk thistle and NAC. This makes the strain a bit easier to put up with during the cycle so the recovery in the PCT stage is enhanced.
The most popular products for cycle support is Nature's Aid Milk Thistle and Pure Labs Cycle Shield . Cycle Shield, while pricier is a far more complete formula for on cycle protection.
In regard to complete PCT products, two of the best are Pure Labs Clomadex PCT . A potent AI known as arimistane, but also tackles other issues.
In the case of Clomadex, it is a masterpiece of formulation. You have proven ingredients such as Fadogia, Vitamin D3 and Mucuna for testosterone, libido and helping with prolactin. Arimistane anti-estrogen for controlling estrogen levels so they don't rebound, which helps combat gynocomastia as well.
Don't forget to keep your intensity up during the PCT stage. This helps keep gains.
Besides the above mentioned ingredients, there are other ways to combat each side effect and it is up to you to do your research and find out what you would prefer to use. Use this article as a starting point to expand your knowledge. After all, knowledge is power.