Corticosteroid-induced osteoporosis

The most effective management is discontinuation of the drug and administering anti-glaucoma medications till the IOP is reduced. If the patient's underlying medical condition can tolerate discontinuation of corticosteroids, then cessation of the medication usually will result in normalization of IOP. In the case of topical corticosteroid drops, a lower potency steroid medication such as the phosphate forms of prednisolone and dexamethasone, rimexolone, loteprednol etabonate, fluorometholone, or medrysone may be substituted. These lower potency drugs have a lesser propensity to raise the IOP, but they usually are not as effective as anti-inflammatory drugs. Topical nonsteroidal anti-inflammatory medications are other alternatives that have no potential to elevate IOP, but they may not have enough anti-inflammatory activity to treat the patient's underlying condition. If sub-Tenon depot steroids are causing an elevation of IOP, they should be excised and removed. It is important to remember that steroid may also cause a rise in the IOP after a filtering surgery and in such patients low potency steroids should be substituted and rapidly tapered.

The distinction between the various types of contact dermatitis is based on a number of factors. The morphology of the tissues, the histology, and immunologic findings are all used in diagnosis of the form of the condition. However, as suggested previously, there is some confusion in the distinction of the different forms of contact dermatitis. [17] Using histology on its own is insufficient, as these findings have been acknowledged not to distinguish, [17] and even positive patch testing does not rule out the existence of an irritant form of dermatitis as well as an immunological one.

Monday 9:00 am - 4:30 pm Tuesday Closed Wednesday 9:00 am - 4:30 pm Thursday Closed Friday 9:00 am - 4:30 pm Saturday Closed Sunday Closed

In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [46] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [47] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

The association linking corticosteroid therapy with the development of posterior subcapsular cataracts has been well documented. These drugs are widely used therapeutically, principally to capitalize on their ability to inhibit inflammatory responses. The literature on corticosteroid-induced posterior subcapsular cataracts is reviewed here. Data from the previously published series and individual lens susceptibility to corticoids do not allow the establishment of a direct factor relating cataract formation to corticosteroid dose and the duration of therapy; however, significant progress has been made in elucidating the mechanism by which corticoids bring about the development of these opacities. Exploration into the development of these lesions has shed light on the similarities these opacities share with other cataracts, especially with regard to location and pathogenesis.

Corticosteroid-induced osteoporosis

corticosteroid-induced osteoporosis

In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [46] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [47] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

Media:

corticosteroid-induced osteoporosiscorticosteroid-induced osteoporosiscorticosteroid-induced osteoporosiscorticosteroid-induced osteoporosiscorticosteroid-induced osteoporosis

http://buy-steroids.org