A single application of 30g clobetasone butyrate % ointment to eight patients resulted in a measurable rise in plasma clobetasone butyrate levels during the first three hours but then the levels gradually decreased. The maximum plasma level reached in the first three hours was /ml. This rise in levels was followed by a more gradual decline with plasma levels of clobetasone butyrate falling below /ml (the lower limit of the assay) after 72 hours. The normal diurnal variation in plasma cortisol levels was not affected by the application of clobetasone butyrate ointment.
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