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Of the type 1 agents, exemestane is considerably more potent than formestane. Of the type 2 agents, letrozole tends to be the most potent in regards to estrogen suppression. In fact, users often complain that letrozole is too suppressive, leading to weakness, achy joints and sometimes injury. But again in each case this may be dose dependent more so than a question of effectiveness of the drug itself. In vivo (tested in live subjects rather than a test tube), the aromatase inhibitors can be graded as shown in the basic table shown above.