The first Aztecs arrived to the Oaxaca area in 1250, but true expansion into the region began in the 15th century. In 1457, Moctezuma I invaded the Tlaxiaco and Coixtlahuaca areas, gaining control, demanding tribute and establishing military outposts.  These were Mixtec lands at first, pushing these people even further into Zapotec territory.  Under Axayacatl and Tizoc , the Aztec began to take control of trade routes in the area and part of the Pacific Coast. By this time, the Zapotec were led by Cosijoeza with the government in Zaachila in the latter 15th century. Under Ahuitzotl , the Aztecs temporarily pushed the Zapotecs into Tehuantepec and established a permanent military base at Huaxyacac (Oaxaca city). The Aztecs were stopped only by the Spanish Conquest  These conquests would change most of the place names in parts of Oaxaca to those from the Nahuatl language.  In 1486 the Aztecs established a fort on the hill of Huaxyácac (now called El Fortín), overlooking the present city of Oaxaca. This was the major Aztec military base charged with the enforcement of tribute collection and control of trade routes. 
* This information is currently accurate. In rare instances, it may be necessary for FDA to change a drug’s new molecular entity (NME) designation or the status of its application as a novel new biologics license application (BLA). For instance, new information may become available which could lead to a reconsideration of the original designation or status. If changes must be made to a drug’s designation or the status of an application as a novel BLA, the Agency intends to communicate the nature of, and the reason for, any revisions as appropriate.