Josef Breuer, a colleague of Sigmund Freud, observed this in the case of Anna O , who sought help from Breuer for hysteria. Breuer discovered that Anna’s anxieties had resulted from traumatic events that had been repressed, but later manifested themselves physically. For example, she experienced paralysis on one side, which Breuer linked to a dream in which she felt paralysed whilst trying to fend off a snake from her bed-bound father. In Depth Anna O: Sigmund Freud's Case History The life and case study of Anna O: how Sigmund Freud was influenced by one woman's experiences. Learn more
Impaired Renal Function: Decreases in renal function may be anticipated in susceptible individuals treated with ENTRESTO. In patients whose renal function depends upon the activity of the renin-angiotensin-aldosterone system (., patients with severe congestive heart failure), treatment with ACE inhibitors and angiotensin receptor antagonists has been associated with oliguria, progressive azotemia and, rarely, acute renal failure and death. Closely monitor serum creatinine, and down-titrate or interrupt ENTRESTO in patients who develop a clinically significant decrease in renal function.
Salicylates are derivatives of salicylic acid that occur naturally in plants and serve as a natural immune hormone and preservative , protecting the plants against diseases , insects , fungi , and harmful bacteria . [ citation needed ] Salicylates can also be found in many medications , perfumes and preservatives. [ citation needed ] Both natural and synthetic salicylates can cause health problems in anyone when consumed in large doses, [ citation needed ] but for those who exhibit salicylate sensitivity (also known as salicylate intolerance ), even small doses of salicylate can cause adverse reactions.