Neurokinin-1 antagonist dopamine antagonist and corticosteroid

A solution of maleic acid ( g) in IPA ( litres) was added. The mixture was then seeded with orvepitant maleate A (1 g) and the mixture was aged for 1 hour. Iso-octane (10 litres) was added over 30 min. and the mixture further aged for 1 hour. The slurry was cooled to 7°C and was further aged for 90 minutes. The solid formed was filtered and washed with a 1 :1 mixture of IPA/iso-octane (2 x 3 litres). The resulting solid was dried at 40°C under reduced pressure to give the title compound (, 44%). NMR (CD 3 OD) δ (ppm) - (d, 3H), - (m, 1 H), - (q, 1 H), - (m, 1 H), - (m, 3H), - (m, 2H), (s, 3H), - (t, 1 H),

Neurokinin-1 antagonist dopamine antagonist and corticosteroid

neurokinin-1 antagonist dopamine antagonist and corticosteroid

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neurokinin-1 antagonist dopamine antagonist and corticosteroidneurokinin-1 antagonist dopamine antagonist and corticosteroidneurokinin-1 antagonist dopamine antagonist and corticosteroidneurokinin-1 antagonist dopamine antagonist and corticosteroidneurokinin-1 antagonist dopamine antagonist and corticosteroid

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