Biologic drugs . Biologics contain human or animal proteins and can block certain immune cells that are involved in psoriasis. They’re usually recommended for people with moderate to severe psoriasis and are administered via an injection or IV infusion. There are currently three types of biologics that can help treat psoriasis, all of which block immune system chemical messengers that promote inflammation called cytokines. The three types of biologics block the cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 12, interleukin 23, and interleukin 17-A (IL-12, IL-23, and IL-17A, respectively).
Erythrodermic psoriasis (sometimes called exfoliative psoriasis) – The most severe of the psoriasis types, erythrodermic psoriasis is usually found in people with unstable plaque psoriasis. It is known by the wide, fiery outbreak and is accompanied by severe itching and pain. During an outbreak of erythrodermic psoriasis, skin often comes off in “sheets.” Only about three percent of people with psoriasis have this type of psoriasis, and it requires immediate medical attention because it can cause increased heartrate and body temperature changes. Some cases, particularly if left untreated, can lead to protein and fluid loss, shivering episodes, pneumonia and even congestive heart failure.