Steroid hormone actions have classically been studied as genomic signaling molecules. In the last decade, increasing evidence of non-genomic rapid signaling via steroid hormones has come to light. Steroid hormones have been shown to have rapid actions on a number of tissues such as the heart, reproductive organs and brain. With a growing body of evidence citing the importance of non-genomic rapid signaling via steroid hormones it is becoming clearer that rapid signaling may have implications in normal and disease states. Perturbations at different points in signaling cascades originating at the membrane have been linked to pathophysiology in different tissues. This opens up another avenue for identifying and targeting potential diagnostic and therapeutic processes.
We would like to bring to the fore front high impact research studies and insights in this field to stimulate a vibrant discussion of advances to further boost the visibility and importance of this topic. We encourage original research articles as well as review articles that provide a comprehensive overview of cutting edge methodologies and recent studies in the field of non-genomic rapid signaling via steroid hormones.
Effects of Cd on cell proliferation in ht-UtLM cells and ht-UtSMCs . To evaluate the effects of Cd exposure on proliferation of human ht-UtLM cells and ht-UtSMCs, we conducted MTS proliferation assays using Cd at concentrations of μM to 200 μM. Compared with vehicle controls, ht-UtSMCs and ht-UtLM cells incubated with Cd for 24 hr, 48 hr, or 72 hr showed statistically significant proliferative responses as measured by absorbance at 490 nm, ( Figure 1A,B ). Therefore, we chose two representative intermediate doses ( and 10 μM) to carry out further mechanistic studies.