Taken together, CDK-1 and CDK-4 act in G 2 /M and G 1 , respectively, like their mammalian orthologs Cdk-1 and Cdk4/6. It is currently not clear whether C. elegans also uses a Cdk2 ortholog, which acts subsequent to Cdk4/6 in mammals to promote G 1 /S and S phase progression. The best candidate is , which shares 43% amino-acid identity with human Cdk2 ( Boxem et al., 1999 ). Inhibition of this gene by RNAi resulted in a variable phenotype, with animals arresting during embryogenesis, during early or late larval development, and as sterile adults.
This year’s Scott Trial is fast approaching, so all you riders who fancy riding the famous course and sections alongside current and past World, European and British champions, get your entries filled in and sent before the closing date of 8th September 2017. The new Scott secretary Ken Wallis scottsecretary@ is busy getting all the land permissions in place while taking the entries and attending to all the other paperwork which goes with the running of this famous trial. The Clerk of the Course Paul Robinson, with his assistants has already been plotting the route which promises to have more new sections on new routes as well as keeping the traditional sections for both riders and spectators.
The word 'dialectically' is not widely understood, and yet carries an essential meaning, namely 'conflicting' (its ancient Greek root means 'debate' - and I thank P Stern for helping clarify this precise meaning). Kolb meant by this that we cannot do both at the same time, and to an extent our urge to want to do both creates conflict, which we resolve through choice when confronted with a new learning situation. We internally decide whether we wish to do or watch , and at the same time we decide whether to think or feel .