My dad takes metformin for his diabetes (ok, so his entire side of the family takes it for diabetes— PCOS and diabetes run through out my family history) and he suggested that I start with 1 a day for 2 weeks and then work up to my 2 a day suggested dose after that. I have found that waiting for my meal to settle a little while (usually about 15-20 minutes really helped me to avoid a lot of discomfort. I already have bathroom “issues” (I tend to go A LOT; a very regulated 30 minutes after I put anything in my mouth) so by waiting it just kind of wrapped into my normal habit and seemed a lot less intense.
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Prescription naproxen comes as a regular tablet, an enteric coated tablet (delayed-release tablet), an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. The extended-release tablets are usually taken once a day. The tablets, enteric coated tablets, and suspension are usually taken twice a day for arthritis. The tablets and suspension are usually taken every 8 hours for gout, and every 6 to 8 hours as needed for pain. If you are taking naproxen on a regular basis, you should take it at the same time(s) every day.