Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]
A common side effect we hear a lot about is in regards to anabolic steroids possible negative effect on the liver. While this can be a problem its important to understand why and what you can do to prevent it. While steroids side effects surrounding the liver are very real, in-short the largest cause for this problem is the use of oral anabolic steroids; in general, injectable steroids will not cause a problem. Further, this does not mean we cannot use oral anabolic steroids but abuse of orals is a higher risk than with injectables. By keeping our oral steroid use to one oral at a time, using orals for shorter durations as well as taking an herbal liver support supplement will greatly ease any negative steroids side effects you may incur with steroid use.