Other significant adverse effects of testosterone supplementation include acceleration of pre-existing prostate cancer growth in individuals who have undergone androgen deprivation; increased hematocrit , which can require venipuncture in order to treat; and, exacerbation of sleep apnea .  Adverse effects may also include minor side-effects such as acne and oily skin, as well as, significant hair loss and/or thinning of the hair, which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia , such as finasteride .  Exogenous testosterone may also cause suppression of spermatogenesis , leading to, in some cases, infertility.  It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor PSA and hematocrit levels closely during therapy. 
As is the case with most anabolic steroids, there is a strong risk to reward ratio at play. In many cases, the higher the dose the greater the reward will be; however, the higher the dose goes the higher probability of adverse effects occurring becomes. When planning your steroid cycles this is an important piece of the puzzle to keep in mind; after all, if you fall prey to numerous adverse effects you're not going to find your cycle all that valuable. It must also be stated; while there are standard doses of certain steroids that seem to be well-tolerated by most, as we are all unique individuals with our own genetic response some will be able to tolerate more while others may not be able to tolerate a specific steroid at all at any dose. In the end, regardless of where your total dose falls, understand that you are responsible for yourself and the actions you take.
A total anabolic steroid cycle can last anywhere from 8-16 weeks most commonly, and in some cases, especially in hardcore circles even longer. As for the Trenbolone Enanthate cycle, 8-10 weeks is about all you'll want if your health is to be maintained. For off-season periods of use, the compound can be added in at any time, the frontend or backend of an off-season plan is fine. For some, switching back and forth between Trenbolone and Nandrolone compounds can be a great way to go. For the cutting phase, this is where a Trenbolone Enanthate cycle will almost always be best served at the backend of a plan. You will get more out of this steroid once you're already somewhat lean when it's being used for cutting purposes.